1975年~
・Kenji Sugibayashi, Michihiro Ueda, Tamotsu Koizumi Lag time involved in
the experiments on drug release from ointments. Chem. Pharm. Bull., 23,
3286-3287 (1975).
・Kenji Sugibayashi, Yasunori Morimoto, Tanekazu Nadai, Yoshio Kato, Akihiko
Hasegawa, Takaichi Arita Drug-carrier property of albumin microspheres
in chemotherapy. I. Tissue distribution of microsphere-entrapped 5-fluorouracil
in mice. Chem. Pharm. Bull., 25, 3433-3434 (1977).
・Kenji Sugibayashi, Yasunori Morimoto, Tanekazu Nadai, Yoshio Kato Drug-carrier
property of albumin microspheres in chemotherapy. II. Preparation and tissue
distribution in mice of microsphere-entrapped 5-fluorouracil. Chem. Pharm.
Bull., 27, 204-209 (1979).
・Kenji Sugibayashi, Masayuki Akimoto, Yasunori Morimoto, Tanekazu Nadai,
Yoshio Kato Drug-carrier property of albumin microspheres in chemotherapy.
III. Effect of microsphere- entrapped 5-fluorouracil on Ehrlich ascites
carcinoma in mice. J. Pharmacobio-Dyn., 2, 350-355 (1979).
・Yasunori Morimoto, Kenji Sugibayashi, Yukiya Yamaguchi, Yoshio Kato Detoxication
capacity of a multiple (w/o/w) emulsion for the treatment of drug overdose:
Drug extraction into the emulsion in the gastro-intestinal tract of rabbits.
Chem. Pharm. Bull., 27, 3188-3192 (1979).
・ Yasunori Morimoto, Kenji Sugibayashi, Mutsuo Okumura, Yoshio Kato Biomedical
applications of magnetic fluids. I. Magnetic guidance of ferro-colloid-entrapped
albumin microsphere for site specific drug delivery in vivo. J. Pharmacobio-Dyn.,
3, 264-267 (1980).
・Yasunori Morimoto, Masayuki Akimoto, Kenji Sugibayashi, Tanekazu Nadai,
Yoshio Kato Drug-carrier property of albumin microspheres in chemotherapy.
IV. Antitumor effect of single-shot or multiple-shot administration of
microsphere-entrapped 5-fluorouracil on Ehrlich ascites or solid tumor
in mice. Chem. Pharm. Bull., 28, 3087-3092 (1980).
・森本雍憲，杉林堅次，中村祐子，中西邦夫，灘井種一，代田博文，中島元信 Disopyramide phosphate(DIP-P) の体内動態（第
I 報）ラットにおける吸収，分布および排泄. 医薬品研究, 12, 620-625 (1981).
・森本雍憲，杉林堅次，中村祐子，中西邦夫，灘井種一，代田博文，中島元信 Disopyramide phosphate(DIP-P) の体内動態（第II報）ラットにおける静脈内投与後の血中濃度，全身オートラジオグラフィー及び乳汁移行.
医薬品研究, 12, 626-634 (1981).
・Y. Morimoto, M. Akimoto, K. Sugibayashi, T. Nadai, Y. Kato Spectrophotometric
analysis for fluorouracil in biological fluids. Pharmazie, 36, 155-156
(1981). ・Yasunori Morimoto, Kenji Sugibayashi, Yoshio Kato Drug-carrier
property of albumin microspheres in chemotherapy. I. Antitumor effect of
microsphere-entrapped adriamycin on liver metastasis of AH 7974 cells in
rats. Chem. Pharm. Bull., 29, 1433-1438 (1981).
・Yasunori Morimoto, Mutsuo Okumura, Kenji Sugibayashi, Yoshio Kato Biomedical
applications of magnetic fluids. II. Preparation and magnetic guidance
of magnetic albumin microsphere for site specific drug delivery in vivo.
J. Pharmacobio-Dyn., 4, 624-631 (1981).
・ K. Sugibayashi, M. Okumura, Y. Morimoto Biomedical applications of magnetic
fluids. III. Antitumour effect of magnetic albumin microsphere-entrapped
adriamycin on lung metastasis of AH 7974 in rats. Biomaterials, 3, 181-186
(1982).
・Yasunori Morimoto, Yukiya Yamaguchi, Kenji Sugibayashi Detoxication capacity
of a multiple (w/o/w) emulsion for drug overdose. II. Detoxication of quinine
sulfate with the emulsion in the gastro-intestinal tract of rabbits. Chem.
Pharm. Bull., 30, 2980-2985 (1982).
・Shozo Miyazaki, Kuniaki Ishii, Kenji Sugibayashi, Yasunori Morimoto, Masahiko
Takada Antitumor effect of ethylene-vinyl acetate copolymer matrices containing5-fluorouracil
on Ehrlich ascites carcinoma in mice. Chem. Pharm. Bull., 30, 3770-3775
(1982).
・遠藤文夫，藤本 茂，橘川征夫，宮崎 勝，雨宮邦彦，大山欣昭，呉 正信，志村賢範，高橋 修，奥井勝二，森本雍憲，杉林堅次 効果増強を目的とした制癌剤封入アルブミン小球体の基礎的検討.
医学のあゆみ, 123, 809-811 (1982).
・Yasunori Morimoto, Kenji Sugibayashi, Masayuki Akimoto Magnetic guidance
of ferro-colloid-entrapped emulsion for site-specific drug delivery. Chem.
Pharm. Bull., 31, 279-285 (1983).
・藤本 茂，遠藤文夫，森本雍憲，杉林堅次，橘川征夫，奥井勝二 Mitomycin C 封入 microsphereの抗腫瘍性の検討. 癌の臨床,
29, 245-248 (1983).
・藤本 茂，遠藤文夫，橘川征夫，森本雍憲，杉林堅次，奥井勝二 制癌剤を含むbiodegradable microsphere の検討. 癌と化学療法,
10, 1328-1333 (1983).
・S. Fujimoto, F. Endoh, Y. Kitsukawa, K. Okui, Y. Morimoto, K. Sugibayashi,
A. Miyakawa, H. Suzuki Continued in vitro and in vivo release of an antitumor
drug from albumin microspheres. Experientia, 39, 913-916 (1983).
・遠藤文夫，藤本 茂，橘川征夫，宮崎 勝，志村賢範，菅沢寛健，高橋 修，栗原正利，河田 滋，奥井勝二，杉林堅次，森本雍憲 Mitomycin
C microsphere による動注癌化学療法の基礎的検討. 癌と化学療法, 11, 1092-1097 (1984).
・Yasunori Morimoto, Kenji Sugibayashi, Satoshi Sugihara, Ken-ichi Hosoya,
Sukekatsu Nozaki, Yoshihiro Ogawa Antitumor agent poly(amino acid) conjugates
as a drug carrier in cancer chemotherapy. J. Pharmacobio-Dyn., 7, 688-698
(1984).
・Spotwood L. Spruance, Mark McKeough, Kenji Sugibayashi, Fredrika Robertson,
Paul Gaede, Donald S. Clark Effect of Azone and propylene glycol on penetration
of trifluoro-thymidine through skin and efficacy of different topical formulations
against cutaneous herpes simplex virus infections in guinea pigs. Antimicrobial
Agents Chemother., 26, 819-823 (1984).
・Masayuki Akimoto, Kenji Sugibayashi, Yasunori Morimoto Application of
magnetic emulsions for sustained release and targeting of drugs in cancer
chemotherapy. J. Control. Release, 1, 205-215 (1985).
・ Kenji Sugibayashi, Ken-ichi Hosoya, Yasunori Morimoto, William I. Higuchi
Effect of the absorption enhancer, Azone, on the transport of 5-fluorouracil
across hairless rat skin. J. Pharm. Pharmacol., 37, 578-580 (1985).
・Shigeru Fujimoto, Masaru Miyazaki, Fumio Endoh, Osamu Takahashi, Katsuji
Okui, Kenji Sugibayashi, Yasunori Morimoto Mitomycin C carrying microspheres
as a novel method of drug delivery. Cancer Drug Delivery, 2, 173-181 (1985).
・W.M. Shannon, L. Westbrook, W.I. Higuchi, K. Sugibayashi, D.C. Baker,
S.D. Kumar, J.L. Fox, G.L. Flynn, N.F.H. Ho, R. Vaidyanathan Influence
of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous
herpes simplex virus type 1 infection in the hairless mouse with 2',3'-di-O-acetyl
9-β-D- arabinofuranosyladenine and with 5'-O-valeryl 9-β-D-arabinofuranosyladenine.
J. Pharm. Sci., 74, 1157-1161 (1985).
・Yasunori Morimoto, Kenji Sugibayashi, Ken-ichi Hosoya, William I. Higuchi
Penetration enhancing effect of Azone on the transport of 5-fluorouracil
across the hairless rat skin. Int. J. Pharmaceut., 32, 31-38 (1986).
・Ken-ichi Hosoya, Norimasa Shudo, Kenji Sugibayashi, Yasunori Morimoto
Effect of Azone on the percutaneous absorption from gels in hairless rats.
Chem. Pharm. Bull., 35, 726-733 (1987).
・Toshinobu Seki, Kenji Sugibayashi, Yasunori Morimoto Effect of solvents
on the permeation of nicardipine hydrochloride through the hairless rat
skin. Chem. Pharm. Bull., 35, 3054-3057 (1987).
・ Kiyoshi Sato, Kenji Sugibayashi, Yasunori Morimoto Effect and mode of
action of aliphatic esters on the in vitro skin permeation of nicorandil.
Int. J. Pharmaceut., 43, 31-40 (1988).
・ Kenji Sugibayashi, Masabumi Nemoto, Yasunori Morimoto Effect of several
penetration-enhancers on the percutaneous absorption of indomethacin in
hairless rats. Chem. Pharm. Bull., 36, 1519-1528 (1988).
・Kiyoshi Sato, Toshihisa Oda, Kenji Sugibayashi,Yasunori Morimoto Estimation
of blood concentration of drugs after topical application from in vitro
skin permeation data. I. Prediction by convolution and confirmation by
deconvolution. Chem. Pharm. Bull., 36, 2232-2238 (1988).
・ Kiyoshi Sato, Toshihisa Oda, Kenji Sugibayashi, Yasunori Morimoto Estimation
of blood concentration of drugs after topical application from in vitro
skin permeation data. II. Approach by using diffusion model and compartment
model. Chem. Pharm. Bull., 36, 2624-2632 (1988).
・Yasunori Morimoto, Toshinobu Seki, Kenji Sugibayashi, Kazuhiko Juni, Shozo
Miyazaki Basic studies on controlled transdermal delivery of nicardipine
hydrochloride using ethylene-vinyl acetate and ethylene-vinyl alcohol copolymer
membranes. Chem. Pharm. Bull., 37, 2633-2641 (1988).
・Yoichi Adachi, Ken-ichi Hosoya, Kenji Sugibayashi, Yasunori Morimoto Duration
and reversibility of the penetration enhancing effect of Azone. Chem. Pharm.
Bull., 36, 3702-3705 (1988).
・野沢巌，鈴木要介，佐藤秀次，畑中朋美，杉林堅次，森本雍憲 温度感応性物質を用いたニトログリセリン及び硝酸イソソルビド経皮吸収製剤の調製と評価
Drug Delivery System, 3, 427-430 (1988).
・Toshinobu Seki, Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto Percutaneous
absorption enhancer applied to membrane permeation-controlled TTS of nicardipine
hydrochloride. Drug Design and Delivery, 4, 69-75 (1989).
・Mutsuo Okumura, Kenji Sugibayashi, Keizaburo Ogawa, Yasunori Morimoto
Skin permeability of water soluble drugs. Chem. Pharm. Bull., 37, 1404-1406
(1989).
・Mutsuo Okumura, Kenji Sugibayashi, Yasunori Morimoto Effect of several
enhancers on the skin permeation of water soluble drugs. Chem. Pharm. Bull.,
37, 1375-1378 (1989).
・善本隆之，斎藤佑尚，杉林堅次，森本雍憲，塚田理康，上松瀬勝男，小寺洋，松島瑞子，稲田祐二 磁力によるウロキナーゼのターゲティング Drug
Delivery System, 4, 121-122 (1989).
・Kiyoshi Sato, Kenji Sugibayashi, Yasunori Morimoto, Harumi Omiya, Naoyoshi
Enomoto Prediction of in-vitro human skin permeability of nicorandil from
animal data. J. Pharm. Pharmacol., 41, 379-383 (1989).
・Yasunori Morimoto, Hideshi Natsume, Kenji Sugibayashi, Shigeru Fujimoto
Effect of chemoembolization of albumin microspheres containing mitomycin
C on AH272 liver metastasis in rats. Int. J. Pharmaceut., 54, 27-32 (1989).
・森本雍憲，小林茂久，関俊暢，杉林堅次，從二和彦 硝酸イソソルビドの成形パップ剤の調製. 薬剤学, 49, 241-246 (1989).
・湯川上営，杉林堅次，森本雍憲 被膜形成型製剤からのケトプロフェンの経皮吸収に及ぼす種々添加剤の影響. 薬剤学, 49, 254-262 (1989).
・Kenji Sugibayashi, Chiaki Sakanoue, Yasunori Morimoto Utility of topical
formulations of morphine hydrochloride containing Azone and N-methyl-2-pyrrolidone.
Selective Cancer Ther., 5,119-128 (1989).
・Toshinobu Seki, Takeo Kawaguchi, Kenji Sugibayashi, Kazuhiko Juni, Yasunori
Morimoto Percutaneous absorption of azidothymidine in rats. Int. J. Pharmaceut.,
57, 73-75 (1989).
・D.X. Cui, K. Sugibayashi, Y. Morimoto, F.L. Li Study on transdermal absorption
of borneol-salicylic acid eutectic mixture. Acta Pharm. Sinica, 24, 556-559
(1989).
・Hideshi Natsume, Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto,
Toshikatu Shibata, Shigeru Fujimoto Preparation and evaluation of biodegradable
albumin microspheres containing mitomycin C for chemoembolization. Int.
J. Pharmaceut., 58, 79-87 (1990).
・Fumio Urushizaki, Hiroshi Yamaguchi, Kuniko Nakamura, Sachihiko Numajiri,
Kenji Sugibayashi, Yasunori Morimoto Swelling and mechanical properties
of polyvinyl alcohol hydrogel. Int. J. Pharmaceut., 58, 125-142 (1990).
・Toshinobu Seki, Takeo Kawaguchi, Kenji Sugibayashi, Kazuhiko Juni, Yasunori
Morimoto Membrane permeation-controlled transdermal delivery system design:
Influence of controlling membrane and adhesive on skin permeation of isosorbide
dinitrate. Chem. Pharm. Bull., 38, 740-743 (1990).
・Mutsuo Okumura, Yuko Nakamori, Yoji Yoshida, Hidesuke Niwa, Kenji Sugibayashi,
Yasunori Morimoto Effect of monoglycerides on the percutaneous absorption
of papaverine hydrochloride. Drug Design and Delivery, 6, 137-148 (1990).
・Masatoshi Yamaguchi, Keiki Tanno, Kenji Sugibayashi, Yasunori Morimoto
Disintegration tests to measure lot-to-lot variations of vaginal tablets.
Chem. Pharm. Bull., 38, 2314-2316 (1990).
・Masatoshi Yamaguchi, Keiki Tanno, Kenji Sugibayashi, Yasunori Morimoto
A disintegration test for vaginal tablets: Comparison with BP test. J.
Pharm. Pharmacol., 42, 795-796 (1990).
・Toshinobu Seki, Chieko Toeda, Takeo Kawaguchi, Kazuhiko Juni, Kenji Sugibayashi,
Yasunori Morimoto Enhanced transdermal delivery of zidovudine in rats and
human skin. Chem. Pharm. Bull., 38, 3086-3089 (1990).
・Tomomi Hatanaka, Masami Inuma, Kenji Sugibayashi, Yasunori Morimoto Prediction
of skin permeability of drugs. I. Comparison with artificial membrane.
Chem. Pharm. Bull., 38, 3452-3459 (1990).
・ 奥村睦男，丹羽弘亮，保坂義文，杉林堅次，森本雍憲 カプリル酸モノグリセリドならびに塩酸ドパミンを含有したテ－プ剤の有用性 Drug Delivery
System, 6, 61-64 (1991).
・Kiyoshi Sato, Kenji Sugibayashi, Yasunori Morimoto Species differences
in percutaneous absorption of nicorandil J. Pharm. Sci., 80, 104-107 (1991).
・Iwao Nozawa, Yosuke Suzuki, Shuji Sato, Kenji Sugibayashi, Yasunori Morimoto
Application of a thermo-responsive membrane to the transdermal delivery
of non-steroidal-anti-inflammatory drugs and antipyretic drugs. J. Control.
Release, 15, 29-37 (1991).
・Hideshi Natsume, Kenji Sugibayashi, Yasunori Morimoto In vitro release
profile of mitomycin C from albumin microsphere: Extrapolation from macrospheres
to microspheres. Pharm. Res., 8, 185-190 (1991).
・Iwao Nozawa, Yosuke Suzuki, Shuji Sato, Kenji Sugibayashi, Yasunori Morimoto
Preparation of thermo-responsive polymer membranes I. J. Biomed. Mater.
Res., 25, 243-254 (1991).
・Mutsuo Okumura, Yuko Nakamori, Kenji Sugibayashi, Yasunori Morimoto Enhanced
skin permeation of papaverine by medium chain glyceride. Drug Design and
Delivery, 7, 147-157 (1991).
・Iwao Nozawa, Yosuke Suzuki, Shuji Sato, Kenji Sugibayashi, Yasunori Morimoto
Preparation of thermo-responsive membranes II. J. Biomed. Mater. Res.,
25, 577-588 (1991).
・夏目秀視、今水賢、杉林堅次，森本雍憲 担癌動物を用いたシスプラチン含有粘性オレイン酸エチルの有用性. Drug Delivery System,
6, 213-219 (1991).
・杉林堅次、中山 悟、細谷健一、森本雍憲 5-フルオロウラシル及びインドメタシンの皮膚透過性に及ぼすアゾン濃度と溶媒の影響. 薬剤学, 51,
80-86 (1991).
・ Yasunori Morimoto, Hideshi Natsume, Yuichiro Tsukada, Kenji Sugibayashi
Oily drug carriers in cancer chemotherapy. I. Evaluation and application
of viscous oleic acid containing semustine for intra-arterial infusion
therapy. Yakuzaigaku, 51, 100-108 (1991).
・Tomomi Hatanaka, Manami Oguchi, Kenji Sugibayashi, Yasunori Morimoto Influence
of isosorbide dinitrate concentration on its skin permeability from adhesive
matrix devices. Chem. Pharm. Bull., 39, 1802-1805 (1991).
・Iwao Nozawa, Yosuke Suzuki, Shuji Sato, Kazuhiko Juni, Kenji Sugibayashi,
Yasunori Morimoto Preparation and evaluation of biodegradable thermo-responsive
microspheres J. Control. Release, 17, 33-40 (1991).
・T. Seki, T. Kawaguchi, K. Juni, K. Sugibayashi, Y. Morimoto Sustained
transdermal delivery of zidovudine via controlled release of penetration
enhancer. J. Control. Release, 17, 41-48 (1991).
・Takemasa Kokubo, Kenji Sugibayashi,Yasunori Morimoto Diffusion of drug
in acrylic-type pressure-sensitive matrices. I. Influence of physical property
of the matrices on the drug diffusion. J. Control. Release, 17, 68-78 (1991).
・Yasunori Morimoto, Sachihiko Numajiri, Kenji Sugibayashi Effect of ion
species and their concentration on the iontophoretic transport of benzoic
acid through poly(vinyl acetate) membrane Chem. Pharm. Bull., 39, 2412-2416
(1991).
・Kenji Sugibayashi, Satoru Nakayama, Toshinobu Seki, Ken-ichi Hosoya, Yasunori
Morimoto Mechanism of skin permeation-enhancing effect by Laurocapram.
J. Pharm. Sci., 81, 58-64 (1992).
・ Tomomi Hatanaka, Masami Inuma, Kenji Sugibayashi, Yasunori Morimoto Prediction
of skin permeability of drugs. II. Development of composite membrane as
a skin alternative. Int. J. Pharmaceut., 79, 21-28 (1992).
・Yasunori Morimoto, Takemasa Kokubo, Kenji Sugibayashi Diffusion of drugs
in acrylic-type pressure-sensitive matrices. II. Influence of interaction.
J. Control. Release, 18, 113-122 (1992).
・Yasunori Morimoto, Tomomi Hatanaka, Mamami Oguchi, Kenji Sugibayashi,
Masayuki Kobayashi, Masuyuki Kimura A screening method for percutaneous
absorption enhancers appropriate for adhesive matrix devices. S.T.P. Pharma
Sci., 2, 253-258 (1992).
・Takemasa Kokubo, Kenji Sugibayashi, Yasunori Morimoto Mathematical models
describing the drug release kinetics from pressure sensitive adhesive matrix.
J. Control. Release, 20, 3-12 (1992).
・Kenji Sugibayashi, Kenji Mori, Yasunori Morimoto Effect of styrene-butadiene-styrene
copolymer membrane on controlling skin permeation of drugs and solvents.
J. Control. Release, 20, 99-108 (1992).
・ Hideshi Natsume, Masaru Imamizu, Kenji Sugibayashi, Toshikazu Shibata,
Akira Miyagawa, Yasunori Morimoto Oily drug carriers in cancer chemotherapy.
II. Preparation of viscous ethyl oleate for intra-arterial infusion therapy
and its disposition in normal animals. Chem. Pharm. Bull., 40, 1545-1552
(1992).
・ Yasunori Morimoto, Tomomi Hatanaka, Kenji Sugibayashi, Harumi Omiya Prediction
of skin permeability of drugs. Comparison between human and hairless rat
skin. J. Pharm. Pharmacol., 44, 634-639 (1992).
・夏目秀視、坂之上和稔、杉林堅次、森本雍憲、宮川 晃、池口祥一 体内植え込み型架橋ゼラチンフィルムの薬物放出制御に関する基礎的検討 Drug
Delivery System, 7, 381-388 (1992).
・小久保武政、杉林堅次、森本雍憲 種々感圧接着剤（粘着剤）中のプロスタグランジンＥ１の拡散係数の変化と活性化エネルギ－の評価 Drug Delivery
System, 7, 391-395 (1992).
・Teruaki Hayashi, Kenji Sugibayashi, Yasunori Morimoto Calculation of skin
permeability coefficient for ionized and unionized species of indomethacin.
Chem. Pharm. Bull., 40, 3090-3093 (1992).
・畑中朋美、下山 勝、杉林堅次、森本雍憲 エタノ－ルの濃度及び時間依存性経皮吸収促進効果. 薬剤学, 52, 215-223 (1992).（日本薬剤学会優秀論文賞受賞論文）
・Tomomi Hatanaka, Masayuki Shimoyama, Kenji Sugibayashi, Yasunori Morimoto
Effect of vehicles on the skin permeability of drugs: Polyethylene glycol
400-water and ethanol-water binary solvents. J. Control. Release, 23, 247-260
(1993).
・Daisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto,
Masayuki Kobayashi, Masayuki Kimura Feasibility of use of several cardiovascular
agents in transdermal therapeutic systems with l-menthol and ethanol system
on hairless rat and human skin. Biol. Pharm. Bull., 16, 254-258 (1993).
・飯島昌夫、墓田 透、佐藤 宏、杉林堅次、森本雍憲 発泡性坐剤からの炭酸ガスの放出に及ぼすアエロジル200および大豆レシチンの影響. 薬剤学,
53, 55-62 (1993).
・M. Iijima, T. Hakata, H. Sato, K. Sugibayashi, Y. Morimoto Effect of Aerosil
200 on the rheological properties of effervescent suppositories. Yakuzaigaku,
53, 80-87 (1993).
・Yasunori Morimoto, Kenji Sugibayashi, Daisuke Kobayashi, Hisashi Shoji,
Jun-ichi Yamazaki, Masayuki Kimura A new enhancer-coenhancer system to
increase skin permeation of morphine hydrochloride in vitro. Int. J. Pharmaceut.,
91, 9-14 (1993).
・Yoshio Wada, Kae Nakajima, Jun-ichi Yamazaki, Toshinobu Seki, Kenji Sugibayashi,
Yasunori Morimoto Influence of composition of l-menthol-ethanol-water ternary
solvent system on the transdermal delivery of morphine hydrochloride. Biol.
Pharm. Bull., 16, 600-603 (1993).
・飯島昌夫、墓田 透、木村重男、岡部登司男、内野泰秀、佐藤 宏、杉林堅次、森本雍憲 発泡性坐剤の安定性評価. 薬剤学, 53, 102-108
(1993).
・Sachihiko Numajiri, Hidetomo Sakurai, Kenji Sugibayashi, Yasunori Morimoto,
Harumi Omiya, Haruyuki Takenaka, Noriyoshi Akiyama Comparison of depolarizing
and direct current systems on iontophoretic enhancement of transport of
sodium benzoate through human and hairless rat skin. J. Pharm. Pharmacol.,
45, 610-613 (1993).
・河合利雄、大野純男、寺山義泰、芝田俊勝、夏目秀視、杉林堅次、森本雍憲 アテロコラ－ゲンを用いた人工皮膚、結合剤の処理法の違いによる比較. 皮膚,
35, 471-476 (1993).
・Ken-ichi Hosoya, Hiroyuki Kubo, Hideshi Natsume, Kenji Sugibayashi, Yasunori
Morimoto, Shinji Yamashita The structural barrier of absorptive mucosae:
Site difference of the permeability of fluorescein isothiocyanate-labeled
dextran in rabbits. Biopharm. Drug Disp., 14, 685-696 (1993).
・ 久保浩之、細谷健一、夏目秀視、杉林堅次、森本雍憲 Ussing chamber system を用いたインスリンの鼻粘膜透過性の評価. Drug
Delivery System, 8, 461-465 (1993).
・糸部浩之、井上直子、楠美里子、小林大介、木村昌行、石島里穂、夏目秀視、杉林堅次、森本雍憲 ステロイド軟膏剤からの主薬皮膚移行性に及ぼす尿素軟膏剤混合の影響.
薬剤学, 53, 242-248 (1993).
・ Hideshi Natsume, Masaru Imamizu, Kenji Sugibayashi, Toshikazu Shibata,
Akira Miyagawa, Yasunori Morimoto Selective accumulation and tumoricidal
effect of cisplatin suspendend in viscous ethyl oleate on hepatic cancers
in animals after intraarterial infusion. J. Drug Targeting, 1, 207-215
(1993).
・Sachihiko Numajiri, Kenji Sugibayashi, Yasunori Morimoto Noninvasive sampling
of lactic acid by iontophoresis using chloride ion in the body as an internal
standard. J. Pharm. Biomed. Anal., 11, 903-909 (1993).
・Hiroyuki Kubo, Ken-ichi Hosoya, Hideshi Natsume, Kenji Sugibayashi, Yasunori
Morimoto In vitro permeation of several model drugs across the rabbit nasal
mucosa.Int. J. Pharmaceut., 103, 27-36 (1994).
・Daisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto,
Masayuki Kimura Analysis of combined effect of l-menthol and ethanol as
skin permeation enhancers based on 2-layer skin model. Pharm. Res., 11,
96-103 (1994).
・Takemasa Kokubo, Kenji Sugibayashi, Yasunori Morimoto Interaction between
drugs and pressure sensitive adhesives used in transdermal therapeutic
systems. Pharm. Res., 11, 104-107 (1994).
・Ken-ichi Hosoya, Hiroyuki Kubo, Hideshi Natsume, Kenji Sugibayashi, Yasunori
Morimoto Evaluation of enhancers to increase nasal absorption using Ussing
chamber technique. Biol. Pharm. Bull., 17, 316-322 (1994).
・Yoshio Wada, Kae Nakajima, Hirohiko Inada, Kenji Sugibayashi, Yasunori
Morimoto Relationship between phase condition of l-menthol/ethanol/water
ternary solvent system and skin permeation of morphine hydrochloride through
hairless rat skin. Yakuzaigaku, 54, 1-9 (1994).
・Ken-ichi Hosoya, Hiroyuki Kubo, Hideshi Natsume, Kenji Sugibayashi, Yasunori
Morimoto Effect of sodium taurodihydrofusidate on nasal drug delivery:
Difference in its concentration and penetrant molecular weight. Arch. Pharm.
Res., 17, 57-59 (1994).
・Tomomi Hatanaka, Ei-ichiro Manabe, Kenji Sugibayashi, Yasunori Morimoto
An application of the hydrodynamic pore theory to percutaneous absorption
of drugs.Pharm. Res., 11, 654-658 (1994).
・Tomomi Hatanaka, Kazunori Katayama, Tamotsu Koizumi, Kenji Sugibayashi,
Yasunori Morimoto In vitro-in vivo correlation of percutaneous absorption:
Isosorbide dinitrate and morphine hydrochloride. Biol. Pharm. Bull., 17,
826-830 (1994).
・吉田光宏、藤森浩行、浅川英典、石野芳雄、笠井正義、森田豊、大沢重光、杉林堅次、森本雍憲 塩酸エペリゾンのin vitro皮膚透過性とin vivo経皮吸収性.
薬剤学, 54, 88-94 (1994).
・Takayasu Matsuzawa, Yoshio Wada, Masaru Shimoyama, Kae Nakajima, Toshinobu
Seki, Kenji Sugibayashi, Yasunori Morimoto Effect of different routes of
administration on the metabolism of morphine: Disposition of morphine and
its metabolites after topical application. Biopharm. Drug Disp., 15, 665-678
(1994).
・Hiraku Machijima, Hiroyuki Nakamura, Tomomi Hatanaka, Kenji Sugibayashi,
Yasunori Morimoto Effect of several adsorbents on the gastrointestinal
absorption of paraquat. Arch. Pharm. Res., 17, 287-293 (1994).
・山口幸也、佐藤 宏、原田真由美、夏目秀視、杉林堅次、森本雍憲、内山 充 外用剤の溶出試験に関する研究 薬剤学, 54, 253-260 (1994).
・Yu-Hui Chien, Osamu Hosoya, Kenji Sugibayashi, Yasunori Morimoto Effect
of skin surface lipid on the skin permeation of lidocaine from pressure
sensitive adhesive. Biol. Pharm. Bull., 17, 1640-1644 (1994).
・Kenji Sugibayashi, Daisuke Kobayashi, Eiji Nakagaki, Tomomi Hatanaka,
Naoko Inoue, Satoko Kusumi, Masayuki Kobayashi, Masayuki Kimura, Yasunori
Morimoto Difference in enhancing effect of l-menthol, ethanol and their
combination between hairless rat and human skin Int. J. Pharmaceut., 113,
189-197 (1995).
・Tomomi Hatanaka, Kazunori Katayama, Tamotsu Koizumi, Kenji Sugibayashi,
Yasunori Morimoto Time-dependent percutaneous absorption enhancing effect
of ethanol. J. Control. Release, 33, 423-428 (1995).
・ 梶本春彦、杉林堅次、森本雍憲 種々低分子薬物の溶解度パラメ－タと高分子膜透過性 薬剤学, 55, 125-133 (1995).
・Y.H. Cheng, K. Sugibayashi, Y. Morimoto, G.T. Liao, S.X. Hou Feasibility
assessment of skin permeation for the local anesthetic lidocaine. Acta
Pharm. Sinica, 30, 615-620 (1995).
・Yukiya Yamaguchi, Kenji Sugibayashi, Takahiro Takeda, Toshinobu Seki,
Yasunori Morimoto Release of clonidine hydrochloride from pressure sensitive
adhesive matrices prepared by emulsion-type of acrylic polymers. Chem.
Pharm. Bull., 43, 1807-1809 (1995).
・Hideo Ueda, Kenji Sugibayashi, Yasunori Morimoto Skin penetration-enhancing
effect of drugs by phonophoresis. J. Control. Release, 37, 291-297 (1995).
・Daisuke Kobayashi, Shingo Kawabata, Kenji Sugibayashi, Yasunori Morimoto,
Masayuki Kimura In vitro/in vivo difference in skin permeation of nicardipine
hydrochloride when using l-menthol-ethanol systems. Skin Pharmacol., 9,
130-136 (1996).
・夏目秀視、斉藤淳、中村裕行、荻原政彦，杉林堅次、森本雍憲、安田英之、滝口俊男、鈴木義久 口臭原因物質に対する吸着剤の除去効果 薬剤学,
56, 32-39 (1996).
・Ei-ichiro Manabe, Kenji Sugibayashi, Yasunori Morimoto Analysis of skin
penetration enhancing effect of drugs by ethanol-water mixed solvent with
hydrodynamic pore theory. Int. J. Pharmaceut., 129, 211-221 (1996).
・Mihoko Tamura, Toshihiko Sueishi, Kenji Sugibayashi, Yasunori Morimoto,
Kazuhiko Juni, Tetsuya Hasegawa, Takeo Kawaguchi Metabolism of testosterone
and its ester derivatives in organotypic coculture of human dermal fibroblasts
with differentiated epidermis. Int. J. Pharmaceut., 131, 263-271 (1996).
・Yukiya Yamaguchi, Kenji Sugibayashi, Yasunori Morimoto Drug release test
to assess quality of topical formulations marketed in Japan. Drug Develop.
Ind. Pharm., 22, 569-577 (1996).
・Kenji Sugibayashi, Teruaki Hayashi, Tomio Hatanaka, Masahiko Ogihara,
Yasunori Morimoto Analysis of simultaneous transport and metabolism of
ethyl nicotinate in hairless rat skin. Pharm. Res., 13, 855-860 (1996).
・Naoko Inoue, Daisuke Kobayashi, Masayuki Kimura, Michiji Toyama, Isamu
Sugawara, Shinji Itoyama, Masahiko Ogihara, Kenji Sugibayashi, Yasunori
Morimoto Fundamental investigation of a novel drug delivery system - A
transdermal delivery system with jet injection. Int. J. Pharmaceut., 137,
75-84 (1996). ・Hideo Ueda, Masahiko Ogihara, Kenji Sugibayashi, Yasunori
Morimoto Change in the electrochemical properties of skin and the lipid
packing in stratum corneum by ultrasonic irradiation. Int. J. Pharmaceut.,
137, 217-224 (1996).
・Sachihiko Numajiri, Kenji Sugibayashi, Yasunori Morimoto Analysis of in
vitro iontophoretic permeation of sodium benzoate by transport numbers
of the drug and pharmaceutical additives. Chem. Pharm. Bull., 44, 1351-1356
(1996).
・Hideo Ueda, Masahiko Ogihara, Kenji Sugibayashi, Yasunori Morimoto Difference
in the enhancing effects of ultrasound on the skin permeation of polar
and non-polar drugs. Chem. Pharm. Bull., 44, 1973-1976 (1996).
・Hiroyuki Nakamura, Yanee Pongpaibul, Teruaki Hayashi, Kenji Sugibayashi,
Yasunori Morimoto Effect of lipophilic multicomponent system on the skin
permeation of ketotifen fumarate. Int. J. Pharmaceut., 141, 71-80 (1996).
・Hideo Ueda, Rika Isshiki, Masahiko Ogihara, Kenji Sugibayashi, Yasunori
Morimoto Combined effect of ultrasound and chemical enhancers on the skin
permeation of aminopyrine. Int. J. Pharmaceut., 143, 37-45 (1996).
・Teruaki Hayashi, Takako Yamazaki, Yukiya Yamaguchi, Kenji Sugibayashi,
Yasunori Morimoto Release kinetics of indomethacin from pressure sensitive
adhesive matrices. J. Control. Release, 43, 213-221 (1997).
・Yukiya Yamaguchi, Tsutomu Usami, Hideshi Natsume, Takao Aoyagi, Yu Nagase,
Kenji Sugibayashi, Yasunori Morimoto Evaluation of skin permeability of
drugs by newly prepared polymer membranes. Chem. Pharm. Bull., 45, 537-541
(1997).
・Hiroyuki Nakamura, Yoichi Kobayashi, Kenji Sugibayashi, Yasunori Morimoto
The effect of the L-lactic acid-ethanol-isopropyl myristate mixed system
on the skin permeation of several drugs. Drug Delivery System, 12, 101-106
(1997).
・Teruaki Hayashi, Yumiko Iida, Tomio Hatanaka, Takeo Kawaguchi, Kenji Sugibayashi,
Yasunori Morimoto The effects of several enhancers on the simultaneous
transport and metabolism of ethyl nicotinate in hairless rat skin. Int.
J. Pharmaceut., 154, 141-148 (1997).
・李 梅花，上田秀雄，杉林堅次，森本雍憲 角質保湿剤ヒアルロン酸ナトリウムの皮膚浸透に及ぼす超音波照射の影響. Drug Delivery
System, 12, 415-419 (1997).
・ Yoichi Kobayashi, Hiroyuki Nakamura, Kenji Sugibayashi, Yasunori Morimoto
Estimation of action site of L-lactic acid-ethanol-isopropyl myristate
mixed system on the skin permeation of ketotifen. Int. J. Pharmaceut.,
156, 153-162 (1997).
・ 真鍋栄一郎，田中重男，杉林堅次，森本雍憲 脂溶性または水溶性薬物のみの皮膚透過性を促進する添加剤は存在するか？：数種促進剤を用いた研究.
薬剤学，58, 10-16 (1998).
・Sachihiko Numajiri, Hirohiko Inada, Kenji Sugibayashi, Yasunori Morimoto
Iontophoretic transport of morphine across hairless rat skin: Is a further
increase obtained with chemical enhancer ? Yakuzaigaku, 58, 29-36 (1998).
・Osamu Hosoya, Motohiko Sano, Yoshio Wada, Toshinobu Seki, Kenji Sugibayashi,
Kazuhiko Juni, Yasunori Morimoto Effect of several hydrophilic polymers
on the permeation of morphine and salicylic acid through excised hairless
rat skin. Chem. Pharm. Bull., 46, 882-885 (1998).
・Go Yanagimoto, Teruaki Hayashi, Toshinobu Seki, Kazuhiko Juni, Kenji Sugibayashi,
Yasunori Morimoto A new in-situ experimental method to evaluate the cutaneous
disposition of flurbiprofen after topical application in hairless rats.
Pharm. Pharmacol. Commun., 4, 261-265 (1998).
・Satoru Tani, Makoto Noguchi, Yukihide Hosoda, Kenji Sugibayashi, Yasunori
Morimoto Characteristics of spontaneous erythema appeared in hairless rats.
Exp. Anim., 47, 253-256 (1988).
・Yoichi Kobayashi, Misao Miyamoto, Kenji Sugibayashi, Yasunori Morimoto
Enhancing effect of N-acetyl-L-cystein or 2-mercaptoethanol on the in vitro
permeation of 5-fluorouracil or tolnaftate through the human nail plate.
Chem. Pharm. Bull., 46, 1797-1802 (1998).
・ Sachihiko Numajiri, Kenji Sugibayashi, Yasunori Morimoto Constant current
and constant voltage iontophoretic transport of morphine hydrochloride
through hairless rat skin in-vitro. Pharm. Pharmacol. Commun., 4, 529-534
(1998).
・夏目秀視，堀聖一，築根忠司，岩田聡子，宮本操，杉林堅次，森本雍憲，山口正俊 新規吸収促進剤ポリ-L-アルギニンによるペプチド医薬品の経鼻吸収性の改善.
Drug Delivery System, 14, 21-25 (1999).
・ Yoichi Kobayashi, Misao Miyamoto, Kenji Sugibayashi, Yasunori Morimoto
Drug permeation through the three layers of the human nail plate. J. Pharm.
Pharmacol., 51, 271-278 (1999).
・Go Yanagimoto, Teruaki Hayashi, Tetsuya Hasegawa, Toshinobu Seki, Kazuhiko
Juni, Kenji Sugibayashi, Yasunori Morimoto Skin disposition of drugs after
topical application in hairless rats. Chem. Pharm. Bull., 47, 749-754 (1999).
・Motohiko Sano, Osamu Hosoya, Shosei Taoka, Toshinobu Seki, Takeo Kawaguchi,
Kenji Sugibayashi, Kazuhiko Juni, Yasunori Morimoto Relationship between
solubility of chitosan in alcoholic solution and its gelation. Chem. Pharm.
Bull., 47, 1044-1046 (1999).
・Hideshi Natsume, Satoko Iwata, Kazuo Ohtake, Misao Miyamoto, Masatoshi
Yamaguchi, Ken-ichi Hosoya, Daisuke Kobayashi, Kenji Sugibayashi, Yasunori
Morimoto Screening of cationic compounds as an absorption enhancer for
nasal drug delivery. Int. J. Pharmaceut., 185, 1-12 (1999).
・Kenji Sugibayashi, Teruaki Hayashi, Yasunori Morimoto Simultaneous transport
and metabolism of ethyl nicotinate in hairless rat skin after its topical
application and the effect of enzyme distribution on them. J. Control.
Release, 62, 193-200 (1999).
・Kenji Sugibayashi, Go Yanagimoto, Teruaki Hayashi, Toshinobu Seki, Kazuhiko
Juni, Yasunori Morimoto Analysis of skin disposition of flurbiprofen after
topical application in hairless rats. J. Control. Release, 62, 201-208
(1999).
・Katsuya Sakuma, Masayuki Ogawa, Kenji Sugibayashi, Ko-ichi Yamada, Katsumi
Yamamoto The relationship between the tyrosinase inhibitory action and
oxidation-reduction potential of cosmetic whitening ingredients and phenol.
Arch. Pharm. Res., 22, 335-339 (1999).
・Ken-ichi Hosoya, Hiroyuki Kubo, Hideshi Natsume, Kenji Sugibayashi, Yasunori
Morimoto Evaluation of bile acids and fusidate derivatives as nasal absorption
enhancers using an electrophysiological technique. Biol. Pharm. Bull.,
22, 1089-1093 (1999).
・Kenji Mori, Tetsuya Watanabe, Tetsuya Hasegawa, Shuji Sato, Kenji Sugibayashi,
Yasunori Morimoto Effect of cathode and anode positions, frequency of applied
pulse, and electrode materials at electroporation on the in vitro skin
permeation of mannitol: Comparison with iontophoresis. Drug Delivery System,
14, 485-490 (1999).
2000年~
・Eiichiro Manabe, Sachihiko Numajiri, Kenji Sugibayashi, Yasunori Morimoto
Analysis of skin penetration-enhancing mechanism of iontophoresis using
hydrodynamic pore theory. J. Control. Release, 66, 149-158 (2000).
・杉林堅次，伊藤真由子，増岡朋子，長谷川哲也，小林大介，山口正俊，井上直子，糸部浩之，木村昌行，三輪典子，牧村瑞惠 処方箋情報の医薬品開発へのフィードバック：口腔内速崩壊性錠剤を例として.
薬剤学，60, 166-174 (2000).
・Kenji Sugibayashi, Midori Kagino, Sachihiko Numajiri, Naoko Inoue, Daisuke
Kobayashi, Masayuki Kimura, Masatoshi Yamaguchi, Yasunori Morimoto Synergistic
effect of iontophoresis and pretreatment of jet injector on the in vitro
skin permeation of dichlofenac and angiotensin II. J. Pharm. Pharmacol.,
52, 1179-1186 (2000).
・Yasunori Morimoto, Teruaki Hayashi, Shogo Kawabata, Toshinobu Seki, Kenji
Sugibayashi Effect of l-menthol-ethanol-water system on the systemic absorption
of flurbiprofen after repeated topical applications in rabbits. Biol. Pharm.
Bull., 23, 1254-1257 (2000).
・Maki Yoshida, Kenji Mori, Tetsuya Watanabe, Tetsuya Hasegawa, Kenji Sugibayashi
Effect of application voltage and cathode and anode positions at electroporation
on the in vitro permeation of benzoic acid through hairless rat skin. Chem.
Pharm. Bull., 48, 1807-1809 (2000).
・Satoshi Ohmori, Teruaki Hayashi, Masami Kawase, Setsuo Saito, Kenji Sugibayashi,
Yasunori Morimoto Transdermal delivery of a potent analgesic dihydroetorphine:
Kenetics analysis of skin permeation and analgesic effect in hairless rat.
J. Pharm. Pharmacol., 52, 1437-1449 (2000).
・Kenji Sugibayashi, Maki Yoshida, Kenji Mori, Tetsuya Watanabe, Tetsuya
Hasegawa Electric field analysis on the improved skin concentration of
benzoate by electroporation. Int. J. Pharmaceut., 219, 107-112 (2001).
・Kimihiro Sato, Naomi Mitsui, Tetsuya Hasegawa, Kenji Sugibayashi, Yasunori
Morimoto Potential of solubility index for prediction of the skin permeation
rate of 5-ISMN from pressure sensitive adhesive tapes. J. Control. Release,
73, 269-277 (2001).
・Misao Miyamoto, Hideshi Natsume, Satoko Iwata, Kazuo Otake, Masatoshi
Yamaguchi, Daisuke Kobayashi, Kenji Sugibayashi, Motoaki Yamashina, Yasunori
Morimoto Improved nasal absorption of drugs by poly-L-arginine: effects
of concentration and molecular weight of poly-L-arginine on the nasal absorption
of fluorescein isothiocyanate-dextran in rats. Eur. J. Pharm. Biopharm.,
52, 21-30 (2001).
・Misao Miyamoto, Hideshi Natsume, Izumi Satoh, Kazuo Ohtake, Masatoshi
Yamaguchi, Daisuke Kobayashi, Kenji Sugibayashi, Yasunori Morimoto Effect
of poly-L-arginine on the nasal absorption of FITC-dextran of different
molecular weights and recombinat human granulocyte colony-stimulating factor
(rhG-CSF) in rats. Int. J. Pharmaceut., 11, 127-138 (2001).
・Yi. Jin, Masaki Uchida, Cheg-Fa Wang, Hideshi Natsume, Kenji Sugibayashi,
Yasunori Morimoto, Transdermal microparticle delivery by a supersonic-Helios
gun system, Acta Pharm. Sinica, 36, 140-144 (2001).
・Yi Jin, Hideki Ohkuma, Cheg-Fa Wang, Hideshi Natsume, Kenji Sugibayashi,
Yasunori Morimoto Pharmaceutical evaluation of fast-disintegrant tablet
containing nicorandil-loaded particles. Acta Pharm. Sinica, 36, 535-538
(2001).
・Tetsuya Watanabe, Tetsuya Hasegawa, Hideshi Takahashi, Takuya Ishibashi,
Kozo Takayama , Kenji Sugibayashi Utility of three-dimensional cultured
human skin model as a tool to evaluate skin permeation of drugs. Alternative
Animal Testing and Experimentation, 8, 1-14 (2001).
（Effect of penetration enhancers on the permeation of drugs across three-dimensional
cultured human skin model: Comparison with the effects using excised hairless
rat skin. Alternative Animal Testing and Experimentationと合わせて日本動物実験代替法学会優秀論文賞受賞論文）
・Tetsuya Watanabe, Tetsuya Hasegawa, Hidekazu Takahashi, Takuya Ishibashi,
Kenji Sugibayashi Effect of penetration enhancers on the permeation of
drugs across three-dimensional cultured human skin model: Comparison with
the effects using excised hairless rat skin. Alternative Animal Testing
and Experimentation, 8, 15-22 (2001).
（Utility of three-dimensional cultured human skin model as a tool to evaluate
skin permeation of drugsと合わせて日本動物実験代替法学会優秀論文賞受賞論文）
・Misao Miyamoto, Tadashi Tsukune, Seichi Hori, Teruaki Hayashi, Hideshi
Natsume, Kenji Sugibayashi, Yasunori Morimoto Estimation of absorption
rate of α-human atrial natriuretic peptide by the plasma profile and diuretic
effect aftr intarnasal administration in rats Biopharm. Drug Disp., 22,
137-146 (2001).
・Daisuke Yoshida, Tetsuya Hasegawa, Kenji Sugibayashi Targeting of salicylate
to skin and muscle following topical injections in rats. Int. J. Pharmaceut.,
231, 177-184 (2002).
・ Yasunori Morimoto, Yoshio Wada, Toshinobu Seki, Kenji Sugibayashi In
vitro skin permeation of morphine hydrochloride during the finite application
of penetration-enhancing system containing water, ethanol and l-menthol.
Biol. Pharm. Bull., 25, 1134-1136 (2002).
・Tetsuya Watanabe, Tetsuya Hasegawa, Hidekazu Takahashi, Takuya Ishibashi,
Hiroshi Itagaki, Kenji Sugibayashi Utility of MTT assay in three-dimensional
cultured human skin model as an alternative for Draize skin irritation
test: Approach using diffusion law of irritant in skin toxicokinetics-toxicodynamics
correlation. Pharm. Res., 19, 669-675 (2002).
・渡邉哲也、長谷川哲也、高橋秀和、石橋卓也、古澤宏幸、岡畑恵雄、杉林堅次 水晶発振子を用いた薬物の in vitro皮膚透過迅速測定法に関する検討
薬剤学, 62, 36-43 (2002).
・ Masaki Uchida, Yi Jin, Hideshi Natsume, Daikuke Kobayashi, Kenji Sugibayashi,
Yasunori Morimoto Introduction of poly-L-lactic acid microspheres into
the skin using supersonic flow: Effects of helium gas pressure, particle
size and microparticle dose on the amount introduced into hairless rat
skin. J. Pharm. Pharmacol., 54, 781-790 (2002).
・Masaki Uchida, Hideshi Natsume, Daisuke Kobayashi, Kenji Sugibayashi,
Yasunori Morimoto Effects of particle size, helium gas pressure and microparticle
dose on the plasma concentration of indomethacin after bombardment of indomethacin-loaded
poly-L-lactic acid microspheres using a HeliosTM gun system. Biol. Pharm.
Bull., 25, 690-693 (2002).
・Liang Fang, Yoichi Kobayashi, Sachihiko Numajiri, Daisuke Kobayashi, Kenji
Sugibayashi, Yasunori Morimoto
The enhancing effect of a triethanolamine-ethanol-isopropyl myristate mixed
system on the skin permeation of acidic drugs.
Biol. Pharm. Bull., 25, 1339-1344 (2002).
・Kenji Sugibayashi, Tetsuya Watanabe, Tetsuya Hasegawa, Hidekazu Takahashi,
Takuya Ishibashi Kinetic analysis on the in vitro cytotoxicity using living
skin equivalent for ranking the toxic potential of dermal irritants. Toxicology
In Vitro, 16, 759-763 (2002).
・ 金 一、大熊英樹、王 華、夏目秀視、杉林堅次、森本雍憲 薬物の徐放性機能を有する口腔内速崩壊錠の研究 薬学雑誌, 122、989-994
(2002).
・Kumi Katori, Masato Homma, Keisuke Kuga , Iwao Yamaguchi, Kenji Sugibayashi,
Yukinao Kohda, Liquid chromatographic determination of unbound flecainide
in therapeutic drug monitoring, J. Pharm. Biomed. Anal., 32, 375-380 (2003).
・ Kenji Mori, Seiji Tokumoto, Hiroyuki Kubo, Naruhito Higo, Iwao Nozawa,
Shuji Sato, Kenji Sugibayashi, Design and feasibility assessment of topically
applied drug formulations for electroporation, Chem. Pharm. Bull., 51 (6),
617-619 (2003).
・Kenji Mori, Tetsuya Hasegawa, Shuji Sato, Kenji Sugibayashi, Effect of
electric field on the enhanced skin permeation of drugs by electroporation,
J. Control. Release, 90, 171-179 (2003).
・.金 素案、田澤悠子、長谷川哲也、小林大介、井上直子、田利多加子、木村昌行、山本利行、山口正俊、杉林堅次
処方箋情報の医薬品開発へのフィードバック２、経口徐放性製剤の適正使用について（Utility of prescription information
for the proper use of sustained release oral formulations）医療薬学, 29(3),
357-366 (2003).
・Yoshihiro Tokudome, Kenji Sugibayashi, The synergic effects of various
electrolytes and electroporation on the in vitro skin permeation of calcein.
J. Control. Release, 92(1-2), 93-101 (2003).
・Yoshihiro Tokudome, Kenji Sugibayashi, The effects of calcium chloride
and sodium chloride on the electroporation-mediated skin permeation of
fluorescin isothiocynate (FITC)-dextrans in vitro, Biol. Pharm. Bull.,
26(10), 1508-1510 (2003).
・ 此松晶子、杉林堅次、岡島眞裕、石井文由（Akiko Konomatsu, Kenji Sugibayashi, Masahiro Okajima,
Fumiyoshi Ishii）特殊還元性マイナスイオン水を用いた界面活性剤フリーエマルションの調製およびその安定性, Preparation
and stability of surfactant free emulsions using electrolyzed deoxidized
and ionized water, Material Technology, 21(6), 273-285 (2003).
・Yoshihiro Tokudome, Kenji Sugibayashi, The mechanism of synergic effects
of calcium chloride and electroporation on the in vitro enhanced skin permeation
of drugs, J. Control. Release, 95(2), 267-274 (2004).
・Y. Kobayashi, T. Komatsu, M. Sumi, S. Numajiri, M. Miyamoto, D. Kobayashi,
K. Sugibayashi, Y. Morimoto, In vitro permeation of several drugs through
the human nail plate: Relationship between physicochemical properties and
nail permeability of drugs, Eur. J. Pharm. Sci., 21(4), 471-477 (2004).
・中山寛之，長谷川哲也，森川明信，杉林堅次、デュロテップ®パッチ繰り返し適用時の血清中フェンタニル濃度挙動の予測 (Prediction of
serum profile of fentanyl after repeated application of Durotep® patch
on skin), TDM研究, 21(3), 248-254 (2004).
・Kenji Sugibayashi, Teruaki Hayashi, Kaori Matsumoto, Tetsuya Hasegawa,
Utility of a three-dimensional cultured human skin model as a tool to evaluate
the simultaneous diffusion and metabolism of ethyl nicotinate in skin,
Drug Metabolism Pharmacokin., 19(5), 352-362 (2004).
・ Masato Homma, Keisuke Kuga, Kumi Katori, Kosuke Doki, Iwao Yamaguchi,
Kenji Sugibayashi, Yukinao Kohda, Assessment of serum flecainide trough
levels in patients with tachyarrhythmia, J. Pharm. Pharmacol., 57, 47-51
(2005).
・.Makiko Osawa, Nobuko Hada, Kaori Matsumoto, Tetsuya Hasegawa, Daisuke
Kobayashi, Yasunori Morimoto, Masatoshi Yamaguchi, Ikuo Kanamoto, Teruaki
Nakagawa, Kenji Sugibayashi Usefulness of coadministration of bucolome
in warfarin therapy. Pharmacokinetic and pharmacodynamic analysis using
outpatient prescriptions, Int. J. Pharmaceut., 293 (1/2), 43-49 (2005).
・Tetsuya Hasegawa, Soan Kim, Mamoru Tsuchida, Yasunori Isshiki, Seiichi
Kondo, Kenji Sugibayashi
Decrease in skin permeation and antibacterial effect of parabens by a polymeric
additive, poly (2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate)
Chem. Pharm. Bull., 53(3), 271-276 (2005).
・Seiji Tokumoto, Kenji Mori, Naruhito Higo, Kenji Sugibayashi, Effect of
electroporation on the iontophoretic permselectivity of hairless mouse
skin, J. Control. Release, 105(3), 296-304 (2005).
・Rakan Matsui, Masaaki Hasegawa, Masami Ishida, Toshiya Ebata, Noriyuki
Namiki, Kenji Sugibayashi, Skin permeation of lidocaine from crystal suspended
oily formulations, Drug Develop. Ind. Pharm., 31(8), 729-738 (2005).
・Kazuhiro Inoue, Kengo Ogawa, Jun’ichi Okada, Kenji Sugibayashi, Enhancement
of skin permeation of ketotifen by supersaturation generated by amorphous
form of the drug, J. Control. Release, 108(2/3), 306-318 (2005).
・Nobuko Hada, Tetsuya Hasegawa, Hidekazu Takahashi, Takuya Ishibashi, Kenji
Sugibayashi Evaluation of dermal patch consisting of cultured skin with
tetracycline HCl and chloramphenicol: mathematical approach, J. Control.
Release, 108(2/3), 341-350 (2005).
・Satoshi Kano, Kenji Sugibayashi, Kinetic analysis on the skin disposition
of cytotoxicity as an index of skin irritation produced by cetylpyridinium
chloride: Comparison of in vitro data using a three-dimensional cultured
human skin model with in vitro results in hairless mice, Pharm. Res., 23(2),
329-35 (2006).
・Yuki Fujisaki, Tadashi Tsukune, Motomu Funyu, Mutsuo Okumura, Tadashi
Ukigaya, Kenji Sugibayashi, Development of sustained-release tablets containing
sodium valproate: In vitro and in vivo correlation, Drug Develop. Indust.
Pharm., 32(2), 207-217 (2006).
・Koji Yamaguchi, Tetsuya Misui, Toshinori Yamamoto, Rie Shiokawa, Yuko
Nomiyama, Norihisa Ohishi, Yoshinori Aso, Kenji Sugibayashi, Analysis of
in vitro skin permeation of 22-oxacalcitriol having a complicated metabolic
pathway, Pharm. Res., 23(4), 680-688 (2006).
・Xue-Ming Wu, Hiroaki Todo, Kenji Sugibayashi, Effects of pretreatment
of needle puncture and sandpaper abrasion on the in vitro skin permeation
of fluorescein isothiocyanate (FITC)-dextran, Int. J. Pharmaceutics, 316(1,2),
102-108 (2006).
・ 石井 宏、藤堂浩明、長谷川哲也、杉林堅次、緒方宏康、病態変動に伴う薬物の血漿中濃度変動パターンを推定する簡易ソフトの開発
Development of easy-to-use software for inferring quantitative changes
in plasma concentration-time profiles due to changes in clinical conditions,
医療薬学, 32(5), 445-454 (2006).
・Masayuki Akimoto, Yuko Sato, Toshimi Okubo, Hiroaki Todo, Tetsuya Hasegawa,
Kenji Sugibayashi, Conversion of FAD in FMN and ribofravin in plasma: Effects
of temperature control and inhibitor addition in plasma on rat pharmacokinetic
study, Biol. Pharm. Bull., 29(8), 1779-1782 (2006).
・Seiji Tokumoto, Naruhito Higo, Kenji Sugibayashi, Effect of electroporation
and pH on the iontophoretic transdermal delivery of human insulin, Int.
J. Pharmaceutics, 326, 13-19 (2006).
・石井宏、北村敏彦、藤堂浩明、櫻井英知、深堀勝博、杉林堅次、皮膚保湿性に及ぼすコンドロイチン硫酸ナトリウムとヒアルロン酸ナトリウムの併用効果,
薬理と治療, 34(9), 1005-1009 (2006).
Hiroshi Ishii, Toshihiko Hitamura, Hiroaki Todo, Masahiro Fukabori, Kenji
Sugibayashi, Combination effect of sodium chondoritin sulfate and sodium
hyaluronate on the skin moisturization, Jpn. Pharmacol. Ther., 34(9), 1005-1009
(2006).
・ Koji Yamaguchi, Tetsuya Mitsui, Yoshinori Aso, Kenji Sugibayashi, Analysis
of in vitro skin permeation of 22-oxacalcitriol from ointments based on
a two- or three-layer diffusion model considering diffusivity in a vehicle,
Int. J. Pharmaceut., 336(2), 310-318 (2007).
・Xue-Ming Wu, Hiroaki Todo, Kenji Sugibayashi, Enhancement of skin permeation
of high molecular compounds by a combination of microneedle pretreatment
and iontophoresis, J. Control. Release, 118(2):189-95 (2007).
・Daisuke Yoshida, Hiroaki Todo, Tetsuya Hasegawa, Kenji Sugibayashi, Dermatopharmacokinetics
of salicylate following topical injection in rats: Effect of osmotic pressure
and injection volume on salicylate disposition, Int. J. Pharmaceut., 337(1-2),
142-147 (2007).
・飯高大、松本浩、坂下裕子、柳川忠二、横山美恵子、石井宏、藤堂浩明、杉林堅次 (Dai Iidaka, Hiroshi Matsumoto,
Yuko Sakashita, Chuji Yanagawa, Mieko Yokoyama, Hiroshi Ishii, Hiroaki
Todo, Kenji Sugibayashi), MRSA感染症治療におけるテイコプラニンの安全性・有効性調査 (Survey on Safety
and Usefulness of teicoplanin in the treatment of methicillin-resistance
staphylococcus aureus (MRSA) infection), 薬理と治療, 35(2), 121-127 (2007).
・Masayuki Akimoto, Yuko Sato, Eiichi Nemoto, Hiroaki Todo, Tetsuya Hasegawa,
Kenji Sugibayashi, Pharmacokinetic profile of flavin adenine dinucleotide,
flavin mononucleotide and riboflavin following intravenous administration
of riboflavin or its coenzymes in rats, J. Health Sci., 53(3), 332-338
(2007).
・Nokubo Hada, Hiroaki Todo, Fusao Komada, Kenji Sugibayashi, Preparation
and evaluation of gene-transfected cultured skin as a novel drug delivery
system for severely burned skin, Pharm. Res., 24(8), 1473-1479 (2007).
・Tetsuya Hasegawa, Asako Kawazome, Go Yanagimoto, Teruaki Hayashi, Toshinobu
Seki, Masayuki Akimoto, Hiroaki Todo, Kenji Sugibayashi, Analysis of skin
disposition of flurbiprofen after topical application using dual agar gel
discs-inserted rats, Biol. Pharm. Bull., 30 (11), 2135-2140 (2007).
・Tetsuya Hasegawa, Asako Kawazome, Kaori Matsumoto, Go Yayagimoto, Teruaki
Hayashi, Masayuki Akimoto, Hiroaki Todo, Kenji Sugibayashi, Analysis of
skin disposition and metabolism of ethyl nicotinate after topical application
using dual agar gel disc-inserted rats, Biol. Pharm. Bull., 31(1), 85-89
(2008).
・Dianxiu Cao, Toshihiko Kitamura, Hiroaki Todo, Sun Dong Yoo, Kenji Sugibayashi,
Pretreatment effects of moxibustion on the skin permeation of FITC-dextran,
Int. J. Pharmaceut., 354(1-2), 117-125 (2008).
・Koji Yamaguchi, Keiichi Morita, Tetsuya Mitsui, Yoshinori Aso, Kenji Sugibayashi,
Skin permeation and metabolism of a new antipsoriatic vitamin D3 analogue
of structure 16-en-22-oxa-24 carboalkoxide with low calcemic effect, Int.
J. Pharmaceut., 353(1-2), 105-112 (2008).
・北村敏彦、小池真理子、藤堂浩明、岡島眞裕、石井文由、杉林堅次, 電解水を用いた界面活性剤フリーエマルションの作製と皮膚透過性制御に関する研究,
香粧品学会誌, 32(1), 1-9 (2008).
・ 加賀谷孝彦、井上 岳、綾 美咲、松本かおり、長谷川哲也、秋元雅之、厚田幸一郎、杉林堅次, アセトアミノフェン小児用ドライシロップ剤の味覚評価（苦味マスキングに関する評価 第１報）,
薬剤学, 68(4), 281-289 (2008).
・Koji Yamaguchi, Tetsuya Mitsui, Yoshinori Aso, Kenji Sugibayashi, Structure-permeability
relationship analysis of the permeation barrier properties of the stratum
corneum and viable epidermis/dermis of rat skin, J. Pharm. Sci., 97(10),
4391-4403 (2008).
・Daisuke Yoshida, Hiroaki Todo, Tetsuya Hasegawa, Kenji Sugibayash, Effect
of vasoactive agents on the dermatopharmacokinetics and systemic disposition
of model compounds, salicylate and FITC-dextran 4 kDa, following intracutaneous
injection of the compounds, Int. J. Pharmaceut., 356(1-2), 181-186 (2008).
・Kenji Sugibayashi, Hiroaki Todo, Eriko Kimura, Safety evaluation of titanium
dioxide nanoparticles by their absorption and elimination profiles, J.
Toxicol. Sci., 33(3), 293-298 (2008).
・Daisuke Yoshida, Hiroaki Todo, Kenji Sugibayashi, Effect of molecular
weight on the dermatopharmacokinetics and systemic disposition of drugs
after intracutaneous injection , Europ. J. Pharm. Sci., 35(1-2), 5-11 (2008).
・Kazuhiko Inoue, Jun’ichi Okada, Kenji Sugibayashi, The enhancing effect
of six chemical enhancers on the skin permeation of ketotifen through excised
hairless mouse skin from aqueous donor solution buffered at pH 5 or pH
10, J. Drug. Del. Sci. Tech., 18(5), 335-341 (2008).（日本薬剤学会優秀論文賞）
・Hiroshi Ishii, Toshihiko Kitamura, Hiroaki Todo, Kenji Sugibayashi, Hidetomo
Sakurai, Masahiro Fukahori, Combined effect of sodium chondroitin sulfate
and sodium hyaluronate on skin moisturization following single and repeated
application, Asian J. Pharm. Sci., 3(3), 94-101 (2008).
・ 関根孝、藤堂浩明、横手よし子、杉林堅次, 化粧品有効成分としての大豆ペプチドの皮膚透過性とその効果に関する研究, 大豆たん白研究, 11,
127-131 (2008).
・Toshihiko Kitamura, Hiroaki Todo, Kenji Sugibayashi, Effect of several
electrolyzed waters on the skin permeation of lidocaine, benzoic acid,
and isosorbide mononitrate, Drug Develop. Ind. Pharm., 35(2), 145-153 (2009).
・H. Ishii, H. Todo, A. Terao, T. Hasegawa, M. Akimoto, K. Oshima, K. Sugibayashi,
Why does a hydrophilic drug permeate skin, although it is not soluble in
white petrolatum?, Drug Develop. Ind. Pharm., 35(11), 1356-1363 (2009).
・ Mariko Koike, Toshihiko Kitamura, Hiroaki Todo, Yoshihiro Tokudome, Fumie
Hashimoto, Yasuniro Isshiki, Siichi Kondo, Kenji Sugibayashi, Bactericidal
activities of several electrolyzed waters, J. Soc. Cosmet. Chem. Jpn.,
43(2), 101-106 (2009)
・ 貝瀬眞由美，山口正俊，杉林堅次, Failure Mode and Effects Analysisを応用して作成したがん化学療法注射処方せん処方監査チェックリストの処方監査未経験者に対する教育効果,
医療薬学, 35(7), 478-486 (2009).
・Y. Tokudome, R. Uchida, T. Yokote , H. Todo , N. Hada, T. Kon, J. Yasuda,
H. Hayashi, F. Hashimoto, K. Sugibayashi, Effect of topically applied sphingomyelin-based
liposomes on the ceramide level in a three dimensional cultured human skin
model, J. Liposome Res., 20, 49-54 (2010).
・K. Sugibayashi, H. Todo, T. Oshizaka, Y. Owada, Mathematical model to
predict skin concentration of drugs: Toward utilization of silicone membrane
to predict skin concentration of drugs as an animal testing alternative,
Pharm. Res., 27(1), 134-42 (2010).
・ 大川原正喜、徳留嘉寛、藤堂浩明、杉林堅次、橋本フミ惠, 静脈内および経口投与後のディオスゲニンのラットにおける体内動態, 薬剤学, 70(1),
82-86 (2010).
・Hiroshi Ishii, Hiroaki Todo, Kenji Sugibayashi, Effect of thermodynamic
activity on skin permeation and skin concentration of triamcinolone acetonide,
Chem. Pharm. Bull., 58(4), 556-561 (2010).
・H. Ishii, H. Todo, K. Sugibayashi, Effect of sebum and ointment rubbing
on the skin permeation of triamcinolone acetonide from white petrolatum
ointment, Biol. Pharm. Bull., 33(5), 876-880 (2010).
・Naoko Inoue, Hiroaki Todo, Dai Iidaka, Yoshihiro Tokudome, Fumie Hashimoto,
Tohru Kishino, Kenji Sugibayashi, Possibility and effectiveness of drug
delivery to skin by needle-free injector, Int. J. Pharmaceut., 391(1-2),
65-72 (2010).
・加賀谷隆彦，井上 岳，綾 美咲，松本かおり，長谷川哲也，濱田ひかり，秋元雅之，厚田幸一郎，杉林堅次, 苦味物質に及ぼすゼリー状嚥下補助食品のマスキング効果（苦味マスキングに関する評価 第2報）,
Food Function, 6(1), 8-15 (2010).
・Hiroaki Todo, Eriko Kimura, Hirotaka Yasuno, Yoshihiro Tokudome, Fumie
Hashimoto, Yoshiaki Ikarashi, Kenji Sugibayashi, Permeation pathway of
macromolecules and nanospheres through skin, Biol. Pharm. Bull., 33(8),
1394-1399 (2010).
・Aranya Manosroi, Walailak Witkittilak, Romchat Chutoprapat, Hiroaki Todo,
Kenji Sugibayashi, Worapaka Manosroi, Jiradej Manosroi, Moisture enhancement
of noisomes entrapped with mineral water in pig ear skin, Chiang Mai J.
Sci., 38(1), 1-13 (2010).
・Keshu Yan, Hiroaki Todo, Kenji Sugibayashi, Transdermal drug delivery
by in-skin electroporation using a microneedle array, Int. J. Pharmaceut.,
397(1-2), 77-83 (2010).
・Satoshi Kano, Hiroaki Todo, Kenichi Sugie, Hidenori Fujimoto, Keiichi
Nakada, Yoshihiro Tokudome, Fumie Hashimoto, Kenji Sugibayashi, Utilization
of reconstructed cultured human skin models as an alternative skin for
permeation studies of chemical compounds, Alternatives to Animal Testing
and Experimentation, 15(2), 61-70 (2010).
・Nanthida Wonglertnirant, Hiroaki Todo, Praneet Opanasopit, Tanasait Ngawhirunpat,
K. Sugibayashi, Macromolecular delivery into skin using hollow microneedles,
Biol. Pharm. Bull., 33(12), 1988-1993 (2010).
・Kenji Sugibayashi, Hiroaki Todo, Kaori Yamaguchi, Effect of negative charged
nano- or micro-particles on the recovery of skin barrier function after
EP application, J. Drug. Del. Sci. Tech., 20(6), 445-450 (2010).（日本薬剤学会優秀論文賞受賞論文）
・Keisuke Yamada, Hiroaki Todo, Jun Yamashita, Keiko Miyamoto, Satoru Hashimoto,
Yoshihiro Tokudome, Fumie Hashimoto, Kenji Sugibayashi, Preparation and
evaluation of liquid-crystal formulations with skin permeation-enhancing
abilities for entrapped drug, J. Oleo Sci., 60(1), 31-40 (2011).（日本油化学会Best
Editor Award受賞論文）
・Hiroshi Ishii, Tsukasa Suzuki, Hiroaki Todo, Mitsuhiro Kamimura, Kenji
Sugibayashi, Iontophoresis-facilitated delivery of prednisolone through
throat skin to the trachea after topical application of its succinate salt,
Pharm. Res., 28(4), 839-847 (2011).
・Dianxiu Cao, Yuko Tazawa, Hiroshi Ishii, Hiroaki Todo, Kenji Sugibayashi,
Pretreatment effects of moxibustion on the skin permeation and skin and
muscle concentrations of salicylate in rats, Int. J. Pharmaceut., 407,
105-110 (2011).
・Yoshihiro Tokudome, Miyuki Jinno, Hiroaki Todo, Tatsuhiko Kon, Kenji Sugibayashi,
Fumie Hashimoto, Increase in ceramide level after application of various
sizes of sphingomyelin liposomes to a cultured human skin model, Skin Pharmacol.
Physiol., 24, 218-223 (2011).
・ Hiroyuki Takeuchi, Shuichi Terasaka, Takanobu Sakurai, Atsushi Fujiya,
Hidetoshi Urano, Kenji Sugibayashi, Variation assessment for in vitro permeabilities
through Yucatan micropig skin, Biol. Pharm. Bull., 34(4), 555-561 (2011).
・Kaori Matsumoto, Eiichi Nemoto, Tetsuya Hasegawa, Masayuki Akimoto, Kenji
Sugibayashi, In vitro characterization of the cytochrome P450 isoforms
involved in the metabolism of 6-methoxy-2-naphtyhlacetic acid, an active metabolite
of the prodrug nabumetone, Biol. Pharm. Bull., 34(5), 734-739 (2011).
・Nanthida Wonglertnirant, Tanasait Ngawhirunpat, Praneet Opanasopit, Hiroaki
Todo, K. Sugibayashi, A hollow microneedle carrier for enhancing skin penetration
of large molecular compounds, Adv. Mater. Res., 194-196, 549-553 (2011).
・ Hiroyuki Takeuchi, Yoko Mano, Shuichi Terasaka, Takanobu Sakurai, Atsushi
Fujiya, Hidetoshi Urano, Kenji Sugibayashi, Usefulness of rat skin as a
substitute for human skin in the in vitro skin permeation study, Exp. Anim.,
60(4), 373-384 (2011).
・Shin-ichi Harada, Eijiro Horisawa, Satoshi Kano, Kenji Sugibayashi, Formulation
study of topically applied O/W lotion containing vitamin D3 derivative,
focusing on skin permeability of the drug, Drug Develop. Ind. Pharm., 37(8),
917-925 (2011).
・Satoshi Kano, Hiroaki Todo, Katsunori Furui, Kenichi Sugie, Yoshihiro
Tokudome, Fumie Hashimoto, Hajime Kojima, Kenji Sugibayashi, Comparison
of several reconstructed cultured human skin models by microscopic observation:
Their usefulness as an alternative membrane for skin in drug permeation
experiments, Alternatives to Animal Testing and Experimentation, 16, 51-58
(2011).
・Hiroyuki Takeuchi, Masahiro Ishida, Atsushi Furuya, Hiroaki Todo, Kenji
Sugibayashi, Influence of skin thickness on the in vitro permeabilities
of drugs through SD rat or Yucatan micropig skin, Biol. Pharm. Bull., 35(2),
192-202 (2012).
・Hiroshi Ishii, Konomi Fujino, Hiroaki Todo, Kenji Sugibayashi, Evaluation
of the skin blanching of topically applied steroids using chromameter in
animals
Exp. Anim., 61(2), 147-156 (2012).
・Kazuhiro Inoue, Kenji Sugibayashi, In vivo enhancement of transdermal
absorption of ketotifen by supersaturation generated by amorphous form
of the drug, Europ. J. Pharm. Sci., 47, 228-234 (2012).
・Daisuke Horita, Hiroaki Todo, Kenji Sugibayashi, Effect of ethanol pretreatment
on the skin permeation of drugs, Biol. Pharm. Bull., 35(8), 1343-1348 (2012).
・ 武内博之、石田真大、浦野英俊、杉林堅次, Yucatan micropig皮膚を介したin vitro透過性からニコチンテープまたはリドカインテープを人に適用後の血中濃度の予測,
薬剤学, 72(4), 251-261 (2012).（薬剤学会優秀論文賞受賞論文）
・Takeshi Oshizaka, Hiroaki Todo, Kenji Sugibayashi, Effect of direction
(epidermis-to-dermis and dermis-to-epidermis) on the permeation of several
chemical compounds through full-thickness skin and stripped skin, Pharm.
Res., 29, 2477-2488 (2012).
・Eriko Kimura, Yuichiro Kawano, Hiroaki Todo, Yoshiaki Ikarashi, Kenji
Sugibayashi, Measurement of skin permeation/penetration of nanoparticles
for their safety evaluation, Biol. Pharm. Bull., 35(9), 1476-1486 (2012).
・ Yoshihiro Tokudome, Kyosuke Nakamura, Madoka Kage, Hiroaki Todo, Kenji
Sugibayashi, Fumie Hashimoto, Effects of soybean peptide and collagen peptide
on collagen synthesis in normal human dermal fibroblasts, Int. J. Food
Sci. Nutr., 63(6), 689-695 (2012).
・ Kazuhiro Inoue, Kenji Sugibayashi, Mathematical analysis of the release
of ketotifen from silicone pressure sensitive adhesive matrices containing
its crystalline or amorphous form, J. Chem. Eng. Japan, 45(11), 881-887
(2012).
・ Masaki Okawara, Yoshihiro Tokudome, Hiroaki Todo, Kenji Sugibayashi,
Fumie Hashimoto, Enhancement of diosgenin distribution in the skin by cyclodextrin
complexation following oral administration, Biol. Pharm. Bull., 36(1),
36-40 (2013).
・Mitsuhiro Kamimura, Atsuo Mouri, Kazuo Takayama, Tomonori Mizutani, Yoichiro
Hamamoto, Motoyasu Iikura, Kaneyuki Furihata, Hiroshi Ishii, Kenji Sugibayashi,
Transdermal application of steroid to cervical trachea for the cough in
patients with bronchial asthma and cough variant asthma: A pilot study,
J. Allergy Ther., 4, 1000152 (2013).
・ Sachie Yoshino, Tomoaki Mitoma, Keiko Tsuruta, Hiroaki Todo, Kenji Sugibayashi,
Effect of emulsification on the skin permeation and UV protection of catechin,
Pharm. Develop. Tech., 19(4), 395-400 (2014).
・ Masaki Okawara, Yoshihiro Tokudome, Hiraoaki Todo, Kenji Sugibayashi,
Fumie Hashimoto, Effect of β–cyclodextrin derivatives on the diosgenin
absorption in Coco-2 cell monolayer and rats, Biol. Pharm. Bull., 37(1),
54-59 (2014).
・Daisuke Horita, Hiroaki Todo, Kenji Sugibayashi, Analysis of hair follicle
penetration of lidocaine and fluorescein isothiocyanate-dextran 4 using
hair follicle-plugging method, Drug Develop. Ind. Pharm., 40(3), 345-351
(2014).
・藤堂浩明、守屋卓幸、井上晴樹、須釜 猛、杉林堅次, 香料成分の皮膚透過性に及ぼす基材の影響, アロマセラピー学雑誌, 14(1), 37-45
(2014).
・Daisuke Horita, Hiroaki Todo, Kenji Sugibayashi, Analysis of the pretreatment
effect of ethanol on the stratum corneum- and hair follicular penetration
of drugs using the hair follicle-plugging method, Chem. Pharm. Bull., 62(6),
578-585 (2014).
・Keisuke Kikuchi, Hiroaki Todo, Kenji Sugibayashi, Usefulness of pressure-sensitive
adhesives as a pretreatment material before application of topical drug
formulations and a peeling tape for excess stratum corneum layers, Chem.
Pharm. Bull., 62(6), 559-567 (2014).
・岡本裕子、赤松浩彦、鹿庭正昭、杉林堅次、寒水孝司、森本隆史, 3次元表皮モデルEPISKINを用いた皮膚刺激性試験代替法の第3者評価報告書
AATEX-JACVAM, 3(1), 1-18 (2014).
・ Masahiro Sugino, Hiroaki Todo, Takamasa Suzuki, Keiichi Nakada, Kiyomi
Tsuji, Yuji Tokunaga, Hideto Jinno, Kenji Sugibayashi, Safety evaluation
of topically exposed biocides using permeability coefficients and the desquamation
rate at the stratum corneum, J. Toxicol. Sci., 39(3), 475-485 (2014)
・Yutaka Inoue, Yuki Morita, Reimi Satoh, Rumiko Amano, Sachihiko Numajiri,
Ikuo Kanamoto, Kenji Sugibayashi, Investigation of stockpile medicine in
pharmacies and dispensing doctor, Jpn. J. Soc. Pharm., 33(1), 30-35 (2014).
・M. Okawara, F. Hashimoto, H. Todo, K. Sugibayashi, Y. Tokudome, Effect
of liquid crystals with cyclodextrin on the bioavailability of a poorly
water-soluble compound, diosgenin, after its oral administration to rats.,
Int. J. Pharmaceut., 472(1-2), 257-261 (2014).
・Takeshi Oshizaka, Keisuke Kikuchi, Wesam R. Kadhum, Hiroaki Todo, Tomomi
Hatanaka, Konstanty Wierzba, Kenji Sugibayashi, Estimation of skin concentrations
of topically applied lidocaine at each depth profile, Int. J. Pharmaceut.,
475(1-2), 292-297 (2014).
・井上裕、森田有貴、斎藤麗美、天野留美子、沼尻幸彦、金本郁男、杉林堅次, 医師調剤医療施設と保険薬局における備蓄医薬品の調査, 社会薬学, 33(1),
30-35 (2014).
